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Product Info Summary
| SKU: | A02908 |
|---|---|
| Size: | 100ul |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC |
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Product info
Product Name
Anti-Collagen alpha-4(IV) chain COL4A4 Antibody
SKU/Catalog Number
A02908
Size
100ul
Form
Liquid
Description
Boster Bio Anti-Collagen alpha-4 (IV) chain COL4A4 Antibody catalog # A02908. Tested in ELISA, IF, IHC applications. This antibody reacts with Human.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Collagen alpha-4(IV) chain COL4A4 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02908)
Host
Rabbit
Contents
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human COL4A4
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A02908 is reactive to COL4A4 in Human
Applications
A02908 is guaranteed for ELISA, IF, IHC Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
164.038kDa
Background of COL4A4
Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation.
Kajita Y., J. Biol. Chem. 270:22167-22175(1995).
Dempsey L.A., Genomics 49:378-384(1998).
Tolnay M., Biochem. J. 338:417-425(1999).
Grosset C., Cell 103:29-40(2000)
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:5000
Validation Images & Assay Conditions
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Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Collagen IV alpha4 Antibody. The picture on the right is blocked with the synthesized peptide.
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Immunofluorescence analysis of COS7 cells, using Collagen IV alpha4 Antibody. The picture on the right is blocked with the synthesized peptide.
Protein Target Info & Infographic
Gene/Protein Information For COL4A4 (Source: Uniprot.org, NCBI)
Gene Name
COL4A4
Full Name
Collagen alpha-4(IV) chain
Weight
164.038kDa
Superfamily
type IV collagen family
Alternative Names
Collagen alpha-4(IV) chain COL4A4 ATS2, BFH, CA44 collagen type IV alpha 4 chain collagen alpha-4(IV) chain|Collagen IV, alpha-4 polypeptide|collagen of basement membrane, alpha-4 chain|collagen, type IV, alpha 4
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on COL4A4, check out the COL4A4 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for COL4A4: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Collagen alpha-4(IV) chain COL4A4 Antibody (A02908)
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No publications found for A02908
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Customer Reviews
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